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1 article(s) from Thomas, Laura

A comparative study of the interactions of cationic hetarenes with quadruplex-DNA forming oligonucleotide sequences of the insulin-linked polymorphic region (ILPR)

Darinka Dzubiel,
Heiko Ihmels,
Mohamed M. A. Mahmoud and
Laura Thomas

Beilstein J. Org. Chem. 2014, 10, 2963–2974, doi:10.3762/bjoc.10.314

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Scheme 1: Equilibrium between single-stranded ILPR-DNA a2 and its parallel and antiparallel quadruplex form.

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Figure 1: Structures of ligands 1–6 used in this study.

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Figure 2: A) CD spectra of ILPR-DNA a2 (20 μM) at different temperatures in potassium phosphate buffer (95 mM...

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Figure 3: CD spectra of ILPR-sequence a2 (20 µM) in potassium phosphate buffer (95 mM, pH 7.0; ^__ : immediate...

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Figure 4: Fluorimetric monitoring of thermal DNA-denaturation of the ILPR quadruplex Fa2T (0.2 μM DNA concent...

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Figure 5: Fluorimetric titration of 1a (A), 1b (B), 1c (C), 1d (D) and 1e (E) with a2 in potassium phosphate ...

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Figure 6: Fluorimetric titration of 2 (A), 3 (B), 4 (C), 5 (D) and 6 (E) with a2 in potassium phosphate buffe...

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Figure 7: Job plot from fluorimetric analysis of mixtures of ligands 1e (A), 4 (B) and 6 (C) with ILPR-DNA a2...

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Figure 8: CD spectra of ILPR-DNA a2 in the presence of 1d (A), 1e (B), 2 (C), 4 (D), 5 (E) and 6 (F) at LDR =...

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Published 11 Dec 2014

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